Anti-Emetic APIs
Premium Active Pharmaceutical Ingredients for Nausea and Vomiting Control
About Anti-Emetic APIs
Holiness Pharmaceutical manufactures and exports high-quality Anti-Emetic APIs used for preventing and treating nausea and vomiting. Our portfolio includes 5-HT3 receptor antagonists and dopamine antagonists manufactured under WHO-GMP standards. We serve pharmaceutical companies globally, providing APIs for developing medications that improve quality of life for patients undergoing chemotherapy, surgery, and those with gastrointestinal disorders.
Key Features
- WHO-GMP certified antiemetic manufacturing facility
- Compliance with IP, BP, USP, and EP pharmacopeial standards
- Multiple therapeutic classes for various emetic causes
- Advanced synthesis for selective receptor antagonists
- Chiral purity control where applicable
- Multiple dosage form specifications available
- Complete regulatory documentation and DMF support
- Technical support for oral and parenteral formulations
Application Areas
Chemotherapy-Induced Nausea
Prevention and treatment of nausea and vomiting during cancer chemotherapy
Post-Operative Nausea
Management of nausea and vomiting following surgical procedures and anesthesia
Radiation Therapy
Control of nausea during radiotherapy treatment
Gastroesophageal Disorders
Treatment of nausea, bloating, and gastroparesis
Motion Sickness
Prevention of travel-related nausea and vomiting
Quality Assurance
Our anti-emetic APIs undergo comprehensive quality testing including HPLC analysis for purity and related substances, chiral purity assessment for enantiomeric drugs, polymorphic form characterization, residual solvent analysis, heavy metal testing, and thorough microbiological evaluation including sterility testing for parenteral products. Each batch meets stringent specifications for critical care medications.
Our Anti-Emetic APIs Products
| Product Name | CAS Number | Grade | Form | Actions |
|---|---|---|---|---|
Domperidone Maleate API | 57808-66-9 | IP/USP/BP | API Powder | View Product |
Ondansetron HCl API | 103639-04-9 | IP/USP/BP | API Powder | View Product |
Frequently Asked Questions
What are Anti-Emetic APIs?
Anti-Emetic APIs are active pharmaceutical ingredients that prevent or reduce nausea and vomiting. They include 5-HT3 receptor antagonists (ondansetron) that block serotonin receptors in the gut and brain, and dopamine antagonists (domperidone) that block dopamine receptors. These work through different mechanisms to control various causes of emesis.
Which anti-emetic APIs does Holiness Pharmaceutical manufacture?
We manufacture Ondansetron HCl (5-HT3 receptor antagonist) and Domperidone Maleate (dopamine antagonist). Both products meet IP, BP, and USP standards and are suitable for oral tablets, orally disintegrating tablets, injectable solutions, and other dosage forms used in hospital and outpatient settings.
Why is Ondansetron preferred for chemotherapy-induced nausea?
Ondansetron is highly effective against chemotherapy-induced nausea because it selectively blocks 5-HT3 receptors that mediate chemotherapy-triggered emesis. It has minimal sedation compared to older antiemetics, can be given orally or IV, has predictable pharmacokinetics, and significantly improves quality of life during cancer treatment.
Do you manufacture Ondansetron for parenteral use?
Yes, we manufacture Ondansetron HCl meeting parenteral grade specifications including bacterial endotoxin limits below 5 EU/mg, sterility assurance, controlled particle matter, and pH specifications for IV administration. We provide technical support for developing IV infusion and IM injection products used in hospital oncology departments.
What is the role of Domperidone in gastrointestinal disorders?
Domperidone is a dopamine antagonist that improves gastric motility and reduces nausea. Unlike metoclopramide, it doesn't cross the blood-brain barrier significantly, reducing CNS side effects. It's effective for gastroparesis, functional dyspepsia, and nausea associated with gastrointestinal disorders, making it valuable for chronic conditions.
Can you provide orally disintegrating tablet (ODT) specifications?
Yes, we provide API specifications optimized for ODT formulations including appropriate particle size for rapid dissolution, good compressibility characteristics, and compatibility with fast-dissolving excipients. ODTs are particularly valuable for antiemetics as they don't require water and can be taken by patients experiencing severe nausea.
How do you ensure consistent quality for critical care antiemetics?
We implement strict process controls, validated analytical methods, and comprehensive batch testing. For parenteral products, we conduct additional tests including sterility, bacterial endotoxins, particulate matter, and pH. Our quality systems ensure batch-to-batch consistency critical for medications used in acute care and oncology settings.
What are the storage requirements for anti-emetic APIs?
Anti-emetic APIs should be stored in tightly closed containers protected from light and moisture at controlled room temperature (15-25°C). Ondansetron requires protection from light due to photosensitivity. We provide comprehensive stability data under ICH conditions and specific packaging recommendations to maintain product quality throughout the shelf life.