Anti-Pyretic APIs
Premium Fever-Reducing Active Pharmaceutical Ingredients for Global Healthcare
About Anti-Pyretic APIs
Holiness Pharmaceutical is a leading manufacturer and global exporter of high-quality Anti-Pyretic APIs used for fever reduction and pain relief. Our flagship product, Paracetamol (Acetaminophen), is manufactured under strict WHO-GMP guidelines and serves as one of the world's most widely used and trusted medications. We supply pharmaceutical companies worldwide, supporting the production of safe, effective fever reducers for patients of all ages.
Key Features
- WHO-GMP and ISO certified manufacturing facility
- Compliance with IP, BP, EP, and USP pharmacopeial standards
- Multiple grades for different dosage forms available
- Advanced crystallization technology for optimal particle size
- Comprehensive impurity profiling and control
- Pediatric and adult formulation specifications
- Complete regulatory documentation and DMF support
- High-volume production capacity with consistent quality
Application Areas
Fever Reduction
Safe and effective treatment for fever in adults and children of all ages
Pain Relief
Management of mild to moderate pain including headaches, toothaches, and body aches
Post-Vaccination Fever
Relief from fever and discomfort following immunizations
Cold and Flu Symptoms
Component of combination products for cold and flu symptom relief
Pediatric Use
First-line antipyretic for children due to excellent safety profile
Quality Assurance
Our anti-pyretic APIs undergo rigorous quality testing including HPLC analysis for purity and related substances, comprehensive impurity profiling including 4-aminophenol and 4-chloroacetanilide, residual solvent analysis, heavy metal testing, particle size distribution analysis, and thorough microbiological evaluation. Each batch is certified to meet international pharmacopeial standards ensuring safety for global use.
Our Anti-Pyretic APIs Products
| Product Name | CAS Number | Grade | Form | Actions |
|---|---|---|---|---|
Paracetamol API | 103-90-2 | IP/BP/EP/USP | API Powder | View Product |
Frequently Asked Questions
What are Anti-Pyretic APIs?
Anti-Pyretic APIs are active pharmaceutical ingredients that reduce fever by acting on the hypothalamic heat-regulating center. Paracetamol (Acetaminophen) is the most common antipyretic, working through inhibition of prostaglandin synthesis in the central nervous system, providing safe and effective fever reduction with analgesic properties.
Which anti-pyretic APIs does Holiness Pharmaceutical manufacture?
We specialize in manufacturing Paracetamol API (also known as Acetaminophen) to IP, BP, EP, and USP standards. We offer multiple grades including standard crystalline, micronized for rapid dissolution, and DC (Direct Compression) grades for tablet manufacturing. Each grade is optimized for specific formulation requirements.
What makes Paracetamol the preferred antipyretic for children?
Paracetamol has an excellent safety profile with minimal gastrointestinal side effects, no association with Reye's syndrome (unlike aspirin), predictable pharmacokinetics, and availability in pediatric-friendly formulations like syrups and suspensions. It's recommended by WHO and pediatric organizations worldwide as the first-line antipyretic for children.
What particle size options do you offer for Paracetamol?
We offer multiple particle size ranges: standard grade (50-200 microns) for general use, micronized grade (<50 microns) for rapid dissolution in suspensions and effervescent formulations, coarse grade (200-500 microns) for sachets, and DC grade with optimized flowability for direct compression tablets.
How do you control critical impurities in Paracetamol?
We implement stringent controls for key impurities including 4-aminophenol (limited to <50 ppm), 4-chloroacetanilide (<20 ppm), and other related substances. Our manufacturing process is optimized to minimize impurity formation, and we use validated HPLC methods for routine monitoring ensuring compliance with all pharmacopeial requirements.
Can you provide Paracetamol API for combination products?
Yes, we supply Paracetamol API for combination products with caffeine, antihistamines, decongestants, NSAIDs, and other active ingredients. We provide compatibility studies, stability data in combinations, and technical support for developing fixed-dose combination products for cold, flu, and pain management.
What is the difference between Paracetamol and Acetaminophen?
Paracetamol and Acetaminophen are the same chemical compound (N-acetyl-p-aminophenol). Paracetamol is the name used in most countries following INN (International Nonproprietary Name), while Acetaminophen is the USAN (United States Adopted Name). Our product meets specifications under both names.
What packaging and storage conditions do you recommend?
Paracetamol should be stored in tightly closed containers protected from light and moisture at controlled room temperature (20-25°C). We package in HDPE drums or fiber drums with polyethylene liners. Proper storage is critical as moisture can affect flowability and compressed tablets. Our product maintains specifications for 3 years under recommended storage conditions.